Genomics: Decoding the frequent language of life

About this course

What’s a genome? The genome accommodates all the data a cell must develop, operate, and self-replicate, and all the data wanted for these cells to come back collectively to type an individual, plant, or animal. The genome accommodates the whole genome of an organism, and even smaller genetic buildings that assist regulate when and the way these genes are used.

The flexibility to regrow torn ligaments, clues that may predict the onset of psychological sickness, a plant’s dietary potential, and even its personal life historical past, are all encoded in genome. By taking this course, you will uncover how scientists decode the language of the genome to learn to develop sustainable meals and gasoline provides, enhance illness therapy and prevention. ailments in addition to shield the environment. Professor Robinson is the lead teacher for this course. As well as, every module has a variety of visitor lecturers. These visitor lecturers come from totally different fields of analysis – biology, physics, laptop science and extra – and pursue numerous analysis targets, however they share frequent pursuits. to genetic strategies and applied sciences. Visitor guides embody: – Elizabeth (Lisa) Ainsworth, Affiliate Professor of Plant Biology – Mark Band, Facility Director of Purposeful Geology – Alison Bell, Affiliate Professor of Animal Biology – Jenny Drnevich, Specialist Purposeful Geographic Bioinformatics with Excessive Efficiency Biocomputing – Christopher Fields, Affiliate Director of Excessive Efficiency Biocomputing – Bruce Fouke, Director of the Roy J. Carver Middle for Biotechnology – Glenn Fried, Director of the Carl R. Woese Institute for Core Physics in Genetic Biology – Nigel Goldenfeld, Professor of Physics – Brendan Harley, Assistant Professor in Chemical and Biomolecular Engineering – Alvaro Hernandez, Director Excessive Throughput Genotyping and Sequencing Facility – Victor Jongeneel, former NCSA Director for Bioinformatics and former Director of Excessive Efficiency Organic Computing – Kingsley Boateng, Senior Analysis Specialist with the Carl R Institute Woese on Core Facility in Genomics – Stephen Lengthy, Professor of Plant Biology and Crop Science – Ruby Mendenhall, Affiliate G. Professor of African American Research – William Metcalf, Professor of Microbiology – Karen Sears, Assistant Professor of Animal Biology – Saurabh Sinha, Affiliate Professor of Laptop Science – Lisa Stubbs, Professor of Cell Biology and Improvement – Rachel Whitaker, Affiliate Professor of Microbiology – Derek Wildman, Professor of Molecular and Integrative Physiology – Peter Yau, Director of the Protein Science Facility

Versatile deadlines Versatile deadlines Reset deadlines to suit your schedule.Shareable Certificates Shareable Certificates Examine for a certificates 100% full 100% on-line Get began now immediately and be taught by yourself schedule.About 36 hours to finishOut there languagesSubtitles: Arabic, French, Portuguese (Europe), Serbian, Italian, Vietnamese, German, Russian, English, Spanish, Romanian

Syllabus – What you’ll be taught from this course

Weekfirst

Week 1

Course Orientation

You’ll grow to be accustomed to our course, classmates and studying atmosphere. Orientation can even make it easier to purchase the technical abilities wanted for the course.

What’s genomics and why can we care?

Gene, genome, DNA: these phrases have entered our day by day information and cognitive cycles, however their true that means usually stays unclear. In these classes we goal to present you, not solely an evidence of what Genomics Biology 101 is, however a sensible perspective on why you have an interest in genomics – possibly in methods you do not even notice. Do you care the place your meals comes from, your well being situation is best to develop, which fish will share your aquarium most efficiently? Genomics is the important thing to discovering higher solutions to those and different on a regular basis questions.

Week2

Week 2

What had been the primary genomes like and the way did they work?

You’ll have seen DNA visually represented in a wide range of methods: a twisted ladder, a tangled string, a sloppy X-shaped array, a row of letters. However what’s DNA actually doing, and the way does it relate to genes and genomes? How can scientists transfer from finding out the bodily construction of the genome to understanding its operate? This module will make it easier to grow to be extra comfy with these concepts.

Week3

Week 3

How can we use genomics to know wholesome our bodies and battle illness?

Normally, we solely hear about genes when one thing goes unsuitable – when mutations, errors are made within the DNA sequence, inflicting a illness like cystic fibrosis. However what occurs inside our cells that leads from DNA mutations to the bodily signs of a illness? Why do some mutations trigger optimistic outcomes or don’t change in any respect? To reply these questions, let’s take a better take a look at how info travels from genes, to RNA, to proteins, to all of the bodily buildings and processes that make up dwelling issues.

Week4

Week 4

What can genomes inform us about the right way to develop new organs or new crops?

If all of the cells in all of our physique’s tissues and organs have the identical set of genes, how can they give the impression of being so totally different? How does a hair cell, a white blood cell, or a mind cell know what to do or the place to go? The reply will be discovered by wanting past the construction of the genome, into the period of its exercise. Recognizing how the data saved within the genome can be utilized in versatile methods exhibits us how organisms can evolve and alter over time.

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Week5

Week 5

How do highly effective genomes enable us to foretell well being issues earlier than they occur?

You’ll have heard of “nature versus nurture” or the modern-day reply, “nature AND nurture!” However how does “nurture”, the atmosphere, work via the genome? Can the organic results of expertise be handed on from technology to technology? And what does all of this should do with on a regular basis points, like our bodily and psychological well being? A more in-depth take a look at two mechanisms that assist regulate gene exercise, epigenetic modifications and transcription elements, will present some solutions.

Week6

Week 6

How do the genomes of ecosystem members cooperate or battle?

The world is an unlimited and generally complicated place. Simply as no gene within the genome works in isolation, no dwelling organism on this planet exists in isolation. Within the ultimate module of this course, we discover a number of the wealthy, complicated interactions between dwelling organisms, their genomes, and the world round them.

steadily requested Questions

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