Industrial Biotechnology

About this Course

Fossil fuels have been the first vitality supply for society because the Industrial Revolution. They supply the uncooked materials for the manufacture of many on a regular basis merchandise that we take with no consideration, together with prescription drugs, food and drinks, supplies, plastics and private care.

Because the twenty first century progresses we’d like options for the manufacture of chemical substances which might be smarter, extra predictable and extra sustainable. Industrial biotechnology is altering how we manufacture chemical substances and supplies, in addition to offering us with a supply of renewable vitality. It’s on the core of sustainable manufacturing processes and a sexy various to conventional manufacturing applied sciences to commercially advance and rework precedence industrial sectors yielding increasingly viable options for the environment within the type of new chemical substances, new supplies and bioenergy. This course will cowl the important thing enabling applied sciences that underpin biotechnology analysis together with enzyme discovery and engineering, techniques and artificial biology and biochemical and course of engineering. A lot of this materials will likely be delivered by lectures to make sure that you could have a strong basis in these key areas. We will even contemplate the broader points concerned in sustainable manufacturing together with accountable analysis innovation and bioethics. Within the second a part of the course we’ll take a look at how these applied sciences translate into actual world functions which profit society and affect our on a regular basis lives. This may embody enter from our business stakeholders and collaborators working within the pharmaceutical, chemical substances and biofuels industries. By the tip of this course it is possible for you to to: 1. Perceive enzymatic operate and catalysis. 2. Clarify the applied sciences and methodologies underpinning techniques and artificial biology. 3. Clarify the variety of artificial biology software and talk about the totally different moral and regulatory/governance challenges concerned on this analysis. 4. Perceive the ideas and position of bioprocessing and biochemical engineering in industrial biotechnology. 5. Have an knowledgeable dialogue of the important thing enabling applied sciences underpinning analysis in industrial biotechnology 6. Give examples of business biotechnology merchandise and processes and their software in healthcare, agriculture, effective chemical substances, vitality and the surroundings.

Syllabus – What you’ll be taught from this course

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WEEK

1

2 hours to finish

Enzymes, Enzyme Discovery and Engineering

Enzyme catalysts are central to life. They’re the automobiles for delivering revolutionary bioscience options to chemical substances manufacture, drug discovery, therapeutics and bioprocessing. They’re the important thing enablers within the white biotechnology revolution, offering important parts within the new science of ‘artificial biology’, providing new routes to biofuels, bulk and commodity chemical substances and novel therapeutics.

WEEK

2

2 hours to finish

Strategies in Programs and Artificial Biology

Current advances in our capability to learn and write genome sequences on a big scale have led to an bold imaginative and prescient for a brand new technology of biotechnology, sometimes called Artificial Biology. Artificial Biology goals at turning biology into an engineering self-discipline, by which organism engineers use computational instruments to design organic techniques with novel worthwhile functionalities, that are then constructed utilizing superior high-throughput genetic engineering, and examined by speedy screening applied sciences that acquire diagnostic molecular profiles to drive improved designs in an iterative design-build-test cycle.

This module will introduce the engineering ideas that inform Artificial Biology and the cutting-edge applied sciences that underlie our dramatically growing capability to assemble residing techniques with custom-made functionalities. All levels of the design-build-test cycle for novel biosystems will likely be mentioned, with a particular concentrate on their integration in a unified bioengineering platform. Examples will concentrate on the appliance of Artificial Biology as an enabling know-how for the bioindustry, particularly for the improved microbial manufacturing of high-value chemical substances and medicines. A bit on accountable analysis and innovation will discover the transformative potential of this revolutionary know-how inside a broader socio-economic context, creating consciousness of the moral and political implications of analysis on this subject.

WEEK

3

2 hours to finish

Biochemical and Bioprocess Engineering

Biochemical and bioprocess engineering is worried with the design of processes which contain organic transformations to fabricate a variety of bio-based chemical substances, biopharmaceuticals and biofuels. By means of making use of data of course of constraints, that are often described mathematically, biochemical engineers are capable of design a sequence of built-in course of steps or “unit operations” which collectively make up a bioprocess.

This module will give an appreciation of the important thing position biochemical engineering has in translating discoveries coming from life sciences and artificial biology, comparable to improved microbial platforms for product expression, into economically viable full scale manufacturing processes. Key engineering ideas and the issue fixing strategy required for the design of bioprocesses will likely be taught by a bunch of biochemical engineers from The College of Manchester, College School London and Technical College of Denmark.

WEEK

4

2 hours to finish

Prescription drugs and High-quality Chemical substances

This module appears on the manufacturing of prescription drugs and effective chemical substances utilizing biocatalysis. Particularly, we’ll take a look at remoted biocatalytic transformations utilizing remoted enzymes or entire cells as catalysts to fabricate commercially essential merchandise together with prescription drugs, industrial monomers and private care merchandise.

This module will likely be delivered by Dr Andy Wells of CHEM21, Europe’s largest public-private partnership devoted to the event of producing sustainable prescription drugs led by The College of Manchester and the pharmaceutical firm GlaxoSmithKline. Dr Wells, alongside Dr Tom Dugmore of The College of York, will take a look at six industrial examples of biocatalytic reactions involving six totally different enzyme transformations. Every instance will take a look at the product, manufacturing route, mechanism of the enzyme response and among the sustainability drivers and metrics for adopting IB as a part of the manufacturing route. Over the six examples, various key attributes of enzyme catalysed processes that have to be thought-about for profitable scale-up will likely be examined. These embody selection of free enzyme or entire cell catalyst, co-factors and co-factor recycling, multi-phase reactions, enzyme stability and throughput. Every instance may have various references to the first literature masking the product and enzyme kind for additional studying exterior of the module.